Live influenza virus vaccine and the preparation thereof

Details Live influenza virus vaccine and the preparation thereof Live influenza virus vaccine and the preparation thereof

1978-07-12

1982-03-09

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

435235, 435236, A61K 3912, C12N 700, C12N 704

Patent

active

043189032

ABSTRACT:
The invention relates to a novel influenza virus strain and to the influenza virus vaccine containing said strain.
The new strain, which is the CNCM I-062 strain, is prepared by recombination of the influenza A/PR/8/34 virus strain with the influenza A/Alaska/5/77 virus strain.
The vaccine is prepared by allowing the CNCM I-062 strain to grow in the allantoic cavity of fertile hen's eggs, harvesting and freeze-drying the yielded virus material.
The strain and the vaccine deriving therefrom are valuable for the immunization against influenza caused by influenza type A (H.sub.3 N.sub.2) virus strains.

REFERENCES:
patent: 3953592 (1976-04-01), Peetermans
patent: 3962423 (1976-06-01), Peetermans
patent: 3991179 (1978-11-01), Beare
patent: 4009258 (1977-02-01), Kilbourne
Yamane et al.-Japan J. Med. Sci. Biol., vol. 31 (1978) pp. 431-434.
Nicholson, K. G. et al.-J. Biol. Standardization vol. 7 (1979) pp. 123-136.
Murphy et al.-IVth Intern. Congr. Virol. (The Hague 1978).
Boudreault-Canad. J. Microbiol. vol. 25 (1979) pp. 279-284.
Rott et al.-J. Gen. Virol. vol. 44 (1979), pp. 471-477.
Oxford et al.-Nature vol. 273 (Jun. 9,1978) pp. 778-779.
Hay et al.-Int. Sym. Infl. Immun. Geneva 1977, Develop. Biol. Stand. vol. 39, pp. 15-24.
Cox et al.-Virology vol. 97 (1979) pp. 471-477.
Mahy et al.-Negative Strand Viruses and the Host Cell (1978) Academic Press-Article by Rott et al. pp. 653-662.

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