10'-[.omega.-N-/1,4-diazabicyclo(4,m,o)-alkanyl/-acyl]-phenothia

Details 10'-[.omega.-N-/1,4-diazabicyclo(4,m,o)-alkanyl/-acyl]-phenothia 10'-[.omega.-N-/1,4-diazabicyclo(4,m,o)-alkanyl/-acyl]-phenothia

1974-07-01

1976-12-21

Randolph, John D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424247, G07B27926

Patent

active

039988201

ABSTRACT:
10'-[.omega.-N-/1,4-diazabicyclo (4,m,O)-alkanyl/-acyl]-Phenothiazines having the formula: ##STR1## wherein X=H, Cl, or CF.sub.3 ; n = 1, 2 or 3; and m = 3 or 5; and their pharmaceutically acceptable acidic addition and quaternary salts are pharmacologically active. The most active compound 10'[.beta.N-/1,4-diazabicyclo-(4,3,0)-nonanyl/-propionyl]-2'-chlorophenoth iazine of the formula: ##STR2## is useful as the active ingredient of a medicated compound possessing spasmolytic and coronary-dilatant effect.
The process for producing said compounds comprises reacting an .omega.-chloracyl -2-substituted phenothiazine with a 1, 4-diazabicyclo-(4,m,O)-alaken in an inert solvent medium at a temperature of 50.degree.-140.degree. C followed by isolation of the desired product.

REFERENCES:
patent: 2512520 (1950-06-01), Cusic
patent: 2519886 (1950-08-01), Charpentier
patent: 2591679 (1952-04-01), Cusic
patent: 2694705 (1954-11-01), Cusic
patent: 3055891 (1962-09-01), Cusic
patent: 3320246 (1967-05-01), Cusic et al.
Casagrande et al., Arz. Forsch., vol. 21, pp. 808-811, (1971).
Rao et al., J. Med. Chem., vol. 13, pp. 516-522, (1970).

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