Orally-active nipecotamide glycolamide esters for the treatment

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514318, 514326, 514255, 546189, 546193, 546208, 544360, 544365, A61K 31445, C07D40112

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active

06066651&

ABSTRACT:
Orally-active nipecotamide glycolamide ester derivatives of formula (I): ##STR1## are disclosed as useful in treating platelet-mediated thrombotic disorders.

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Hoekstra W J et al., Design and Evauation of Nonpeptide Fibrinogen Gamma-Chain Based GPIIB/IIIA Antagonists; Jan. 1, 1995; pp. 1582-1592.
Hoekstra WJ et al., Solid Phase Parallel Synthesis Applied to Lead Optimization: Discovery of Potent Analogues of the GPIIB/IIIA Antagonists RWJ-50042; Oct. 22, 1996; pp. 2371-2376.
Hoekstar W J et al., Solid Phase Synthesis Via N-Terminal Attachment to the 2-Chlorotrityl Resin; Apr. 14, 1997; pp. 2629-2632.
Esters of N,N-Disubstituted 2-Hydroxyacetamides as a Novel Highly Biolabile Prodrug Type for Carboxylic Acid Agents; Mar. 1987; pp. 451-454.

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