N,N-bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyeth

Details N,N-bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyeth N,N-bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyeth

1975-10-16

1977-05-17

Wyman, Daniel E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260471C, 260553R, 260562P, 260562A, 26057055, 2605706, 424300, 424311, 424330, A61K 31165, A61K 31135, C07C10364, C07C 9112

Patent

active

040242811

ABSTRACT:
N,N'-Bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyethyl]-polymethylenediamines having .beta.-adrenergic stimulant activity particularly as selective bronchodilators, are prepared generally by condensation of an N-benzylphenethylamine with a polymethylene dihalide or by reaction of an .beta.-bromoacetophenone with an N,N'-dibenzyl-polymethylenediamine, with further operations depending on the nature of the 3-substituent, and subsequently hydrogenating catalytically with for example palladium-on-carbon. The key intermediates are also part of the invention.

REFERENCES:
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patent: 3888829 (1975-06-01), Bastian et al.
patent: 3888898 (1975-06-01), Koppe et al.
patent: 3892799 (1975-07-01), Pinhas
patent: 3917704 (1975-11-01), Kaiser et al.
patent: 3933913 (1976-01-01), Collella et al.

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