Method for preparation of vesicles loaded with biological struct

Details Method for preparation of vesicles loaded with biological struct Method for preparation of vesicles loaded with biological struct

1996-08-13

2000-05-23

Naff, David M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424 937, 424 941, 424520, 435177, 435182, 436528, 436535, 514 2, 514 44, 530812, 530817, A61K 9127, C12N 1102, G01N 33544, C07K 1702

Patent

active

060663316

ABSTRACT:
A composition useful for preparing vesicles loaded with biological cell-structures, biopolymers and/or -oligomers is prepared by solubilizing amphiphatic material such as a phospholipid in a polar-protic solvent miscible with water, solubilizing biological cell-structures, biopolymers and/or -oligomers in an aqueous medium, mixing the polar-protic solvent containing the amphiphatic material with the aqueous medium containing the biological cell-structures, biopolymers and/or -oligomers, and lyophilizing the resultant mixture to form a dry product. The dry product is hydrated in an aqueous medium to form the loaded vesicles. The polar-protic solvent may be tert-butanol, and the aqueous medium may contain a salt such as sodium chloride, an isoosmotic cryoprotectant such as lactose, sucrose or trehalose, or a mixture of the salt and the cryoprotectant. A medicament for disease treatment is formed by mixing the loaded vesicles with a pharmaceutically acceptable vehicle.

REFERENCES:
patent: 4229360 (1980-10-01), Schneider et al.
patent: 4235871 (1980-11-01), Papahadjopoulos et al.

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