Preparation of immortalized cells

Details Preparation of immortalized cells Preparation of immortalized cells

1994-09-09

1997-11-04

Stanton, Brian R.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4351721, 4351723, 435354, 800 2, C12N 506, C12N 518, C12N 1506, C12N 1509

Patent

active

056839065

ABSTRACT:
Cell lines have been prepared from growth suppressor gene deficient animals. The cells include immortalized precursor cells and differentiated cells such as osteoclast precursors, osteoblast precursors, megakaryocytes, osteoclasts, osteoblasts, pancreatic .alpha.-cells, pancreatic .beta.-cells, pancreatic .delta.-cells, adipocytes, macrophages, chondrocytes and hepatocytes. The cells are useful for constructing cDNA and protein libraries, screening agonists and antagonists of compounds and factors that affect metabolic pathways of specific cells and generating cell-specific antibodies.

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