Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1993-02-10
1997-11-04
Achutamurthy, Ponnathapura
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4241921, 4242011, 4242021, 4242031, 4352523, 4353201, 530324, 530350, 536 231, 536 234, 536 235, 536 2353, 536 2372, A61K 3900, C07H 2104, C07K 1400, C12N 1500
Patent
active
056836953
ABSTRACT:
The present invention relates to recombinant proteins encoding at least two antigenic epitopes joined by flexible hinge domains. Proteins of this design enable presentation of each epitope to the immune system and are particularly useful as vaccines against infectious agents, such as viruses, when many variants of that agent exist. Moreover, the recombinant proteins of the invention are useful as a single vaccine composition effective against diverse infectious agents since the subject proteins can have antigenic epitopes from different infectious agents. The invention further provides nucleic acids, expression vectors, host cells and methods for production of the subject recombinant proteins as well as vaccines and methods for treating HIV.
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Shen De Fen
Wang Chang Yi
Achutamurthy Ponnathapura
United Biomedical Inc.
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