Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1990-09-27
1992-07-07
Raymond, Richard I.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514836, 514873, A61K 3119
Patent
active
051283743
ABSTRACT:
Methods for building bone in a human or other animal subject, comprising administering to said subject a safe and effective amount of calcium citrate malate. The calcium citrate malate is preferably administered for at least about three months. A preferred method of the invention is for the treatment of osteoporosis. The calcium citrate malate comprises a complex or a mixture of calcium salts having a ratio of moles citrate to moles malate of from about 1:0.16 to about 1:13.5. The calcium citrate malate is preferably administered in an oral dosage form, containing pharmaceutically-acceptable carriers and excipients.
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L. Nilas et al., "Calcium Supplementation and Postmenopausal Bone Loss", 289 British Medical Journal 1103 (1984).
Spencer et al., "NIH Consensus Conference: Osteoporosis-Factors Contributing to Osteoporosis", 116 J. Nutrition 316 (1986).
Gordan et al., "NIH Consensus Conference: Osteoporosis-Calcium and Osteoporosis", 116 J. Nutrition 319 (1986).
B. Riis et al., "Does Calcium Supplementation Prevent Postmenopausal Bone Loss?", 316 New Engand Journal of Medicine 173 (1987).
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Garrison et al., The Nutrition Desk Reference, (1985) pp. 58-59.
Riggs et al., "Involutional Osteoporosis", 314 New England Journal of Medicine (1986).
Clark Karen F.
Hollinden Gary E.
Raymond Richard I.
Schaeffer Jack D.
Suter David L.
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