Hexahydronaphthalene ester derivatives, their preparation and th

Details Hexahydronaphthalene ester derivatives, their preparation and th Hexahydronaphthalene ester derivatives, their preparation and th

1993-12-28

1995-09-19

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

560127, C07D30930, C07C 6974

Patent

active

054516889

ABSTRACT:
Compounds of formula (I): ##STR1## [wherein R.sup.1 represents a group of formula (II) or (III): ##STR2## R.sup.2 is alkyl, alkenyl or alkynyl; R.sup.3 and R.sup.4 are each hydrogen, alkyl, alkenyl or alkynyl; R.sup.5 is hydrogen or a carboxy-protecting group; R.sup.a is hydrogen or a group of formula and --OR.sup.6 ; R.sup.6, R.sup.6a and R.sup.6b are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulfonyl, halogenated alkanesulfonyl or arylsulfonyl] and their salts and esters have the ability to inhibit the synthesis of cholesterol, and can thus be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.

REFERENCES:
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patent: 5049696 (1991-09-01), Lee et al.
Pike and Brown Nutrition pp. 531-535 (1984).
Patent Abstracts of Japan, unexamined applications, C section, vol. 9, No. 32, The Patent Office Japanese Government, p. 4 C 265, 1985, of JP 59-175450.
The Journal of Organic Chemistry, vol. 51, 1986, Issues 9-14, G. E. Keck et al., "A Highly Convergent Total Synthesis, of (+)-Compactin", pp. 2487-2493.

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