Microcapsule immunoassay and reagents therefor

Details Microcapsule immunoassay and reagents therefor Microcapsule immunoassay and reagents therefor

1987-12-31

1992-07-07

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 772, 435 79, 435 793, 435 18, 435966, 435975, 436519, 436520, 436528, 436821, 436829, G01N 33544

Patent

active

051282410

ABSTRACT:
Microcapsule-reagents are prepared by previously reacting at least a part of an antigen or antibody attached to microcapsules encapsulating a labeling substance with an antibody or antigen which is specifically reactive therewith, and then the reagent thus prepared is reacted with a sample containing an antigen or antibody in the presence of a complement, whereby highly sensitive immunoassay of the antigen or antibody in the sample can be realized even when the antigen or antibody attached to the microcapsules has a lowered activity or has only low reactivity with the antibody or antigen in the sample.

REFERENCES:
patent: 4483921 (1984-11-01), Cole
patent: 4707441 (1987-11-01), Ahmad et al.
Clinical Chemistry, vol. 31, No. 9, Sep. 1985, "A highly sensitive immunoassay system involving anitbody-coated tubes and liposome-entrapped dye", J. P. O'Connel et al., pp. 1424-1426.
W. M. Hunter, in D. M. Weir (ED), Handbook Of Experimental Immunology, Blackwell Scientific Publications, Oxford, 1978, pp. 14.25-14.26.
HSIA et al, Ann. N.Y. Acad. Sci., 308, 139-148, 1978.

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