Cholecystokinin antagonists useful in the treatment of panic att

Details Cholecystokinin antagonists useful in the treatment of panic att Cholecystokinin antagonists useful in the treatment of panic att

1994-02-02

1995-09-19

Jordan, Kimberly R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3140

Patent

active

054516021

ABSTRACT:
Unnatural dipeptoids of .alpha.-substituted Try-Phe derivatives are useful as agents in the treatment of panic disorders. These dipeptoids are CCK.sub.B antagonists having utility in the prevention of panic attacks in patients prone to these attacks.

REFERENCES:
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Arch Gen Psychiatry, vol. 46, Jun. 1989, pp. 511-517, "Cholecystokinin Tetrapeptide Induces Panic-like Attacks in Healthy . . . ", C. de Montigny.
Can J. Psychiatry, vol. 35, Feb. 1990, pp. 83-85, "Cholecystokinin-Tetrapeptide Induces Panic Attacks in Patients . . . ", J. Bradwejn et al.
Ravard, S. and Dourish, C., TIPS, vol. 11, Jul. 1990, 271-273.
Berkow, R., et al., The Merck Manual of Diagnosis and Therapy 15 edition, 1987, 1502-1504.
Abelson, J., et al., Archives of General Psychiatry, vol. 47, No. 4, Apr. 1990, 395.
Horwell, D. C., et al., J. of Med. Chem. 34, No. 1, 1991, 404-414.
Hughes, J., et al., Arzneimittel-Forschung Drug Res. 42(1) No. 2a, 1992, 250-255.

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