Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1989-08-10
1992-07-07
Stoll, Robert L.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
530402, 530408, 5303915, 5303913, 534 14, 436804, 435975, 424 9, A61K 4300, A61K 4902, C07B 5900
Patent
active
051281198
ABSTRACT:
A method for radiolabeling a protein with a radioisotope of technetium of rhenium comprises the steps of contacting a solution of a protein containing a plurality of adjacent free sulfhydryl groups, or in particular cases, intact protein containing at least one disulfide group, with stannous ions, and then with radiopertechnetate or radioperrhenate, the amount of stannous ion being sufficient to substantially completely reduce the radiopertechnetate or radioperrhenate, and recovering radiolabeled protein.
REFERENCES:
patent: Re32417 (1987-05-01), Burchiel
patent: 3725295 (1973-04-01), Eckelman et al.
patent: 4057617 (1977-11-01), Abramovici et al.
patent: 4293537 (1981-10-01), Wong
patent: 4401647 (1983-08-01), Krohn et al.
patent: 4472371 (1984-09-01), Burchiel et al.
patent: 4478815 (1984-10-01), Burchiel et al.
patent: 4500507 (1985-02-01), Wong
patent: 4877868 (1989-10-01), Reno et al.
patent: 5053493 (1991-10-01), Pak et al.
patent: 5061641 (1991-10-01), Shochat et al.
patent: 5078985 (1992-01-01), Rhodes
Covert John M.
Immunomedics Inc.
Stoll Robert L.
LandOfFree
Methods for technetium/rhenium labeling of f(ab.sup.1).sub.2 fra does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for technetium/rhenium labeling of f(ab.sup.1).sub.2 fra, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for technetium/rhenium labeling of f(ab.sup.1).sub.2 fra will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1828319