Certain oxazoloquinolinones; a new class of GABA brain receptor

Details Certain oxazoloquinolinones; a new class of GABA brain receptor Certain oxazoloquinolinones; a new class of GABA brain receptor

1993-11-30

1995-09-19

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 82, 546 83, C07D49804, A61K 3142, A61K 3147

Patent

active

054515858

ABSTRACT:
This invention encompasses compounds of the formula: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and W are variables. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine drugs, and enhancement of memory.

REFERENCES:
patent: 4312870 (1982-01-01), Tokoyama
patent: 4713383 (1987-12-01), Francis et al.
patent: 5182290 (1993-01-01), Albaugh
Merchant and Shirali, Bull. Chem. Soc. of Japan 50: 3075 (1977), "A Simple Method for the Synthesis of 5-Methyloxazolo-[4,5-c]quinolin-4(5H)-ones".

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