Process for the preparation of aryl-substituted propionic acid e

Details Process for the preparation of aryl-substituted propionic acid e Process for the preparation of aryl-substituted propionic acid e

1990-07-18

1992-02-18

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C 6976

Patent

active

050896563

ABSTRACT:
Disclosed is a process for the preparation of aryl-substituted propionic acid esters having the formula: ##STR1## wherein R and R.sup.1 are a C.sub.1 -C.sub.12 linear or branched alkyl, a C.sub.5 -C.sub.12 cycloalkyl, a C.sub.6 -C.sub.12 aryl or a C.sub.7 -C.sub.12 alkaryl or aralkyl, R.sup.2 is hydrogen or a C.sub.1 -C.sub.20 linear or branched alkyl and R.sup.3 is a C.sub.1 -C.sub.20 linear or branched alkyl, a C.sub.5 -C.sub.12 cycloalkyl, a C.sub.6 -C.sub.12 aryl or a C.sub.7 -C.sub.20 alkaryl or aralkyl, and may be the same or different, which comprises forming a reaction mixture of a phenol, at least one base catalyst and an acrylate, in the presence of a complexing agent effective in increasing the rate of reaction, wherein (i) substantially all of the side-product is removed from said reaction mixtrue prior to the addition of the complexing agent and (ii) all or substantially all of the acrylate is added at once to the reaction mixture. The process results in higher yields of the desired product, in a shorter period of time, with a reduction of undesirable by-products.

REFERENCES:
patent: 3247240 (1966-04-01), Meier
patent: 3285855 (1966-11-01), Dexter et al.
patent: 3364250 (1968-01-01), Dexter et al.
patent: 3840585 (1974-10-01), Yamada et al.
patent: 4228297 (1990-10-01), Haeberli et al.
patent: 4529809 (1985-07-01), Irving et al.
patent: 4547585 (1985-10-01), Yamonaka et al.
patent: 4659863 (1987-04-01), Lester
A. A. Volod'kin, et al., --The Reaction Mechanism of the Alkylation of 2,6-Di-Tert-Butyl Phenol by Methyl Acrylate in the Presence of the 2,6-Di-Tert-Butyl Phenolate of Potassium and Alkali, polymer Degradalios & Stability, 26(1989) 89-100.

Affiliated with

Also associated with

Rating

Process for the preparation of aryl-substituted propionic acid e does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of aryl-substituted propionic acid e, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of aryl-substituted propionic acid e will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1825261