Pharmaceuticals and dietetics containing acylamino acid derivati

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514315, 514326, 514422, 514423, 514449, 514450, 514452, 514467, 514549, 514551, 514563, 514616, 546207, 546226, 546245, 548344, 548517, 548540, 548953, 549347, 549372, 549450, 549510, 560170, 562560, 562561, 562562, 562564, 562567, 564159, A61K 31395

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050894927

ABSTRACT:
Acylamino carboxylic acid derivatives corresponding to the formula I ##STR1## in which the groups R.sup.1, R.sup.2, R.sup.3, Z.sup.1 and Z.sup.2 represent functional groups specified in the claims. The acylamino carboxylic acid derivatives have valuable pharmacological properties which, in particular, favorably influence nitrogen metabolism. The compounds are useful as active ingredients in pharmaceutical and/or dietetic compositions for treatment or prevention of nitrogen metabolism disturbances in large mammals caused, for example, by liver or kidney damage.

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Ojima, Chem. Atst., 95:187,642n (1981).
J. H. Close, N. Engl. J. Med. 290, pp. 663-667 (1974).
M. E. Tischler, M. Desautels, A. L. Goldberg, J. Biol.-Chem. 257, pp. 1613-1621 (1982).
G. Francois et al., Clin Nutr. 3, pp. 99-101 (1984).
E. McOmie, "Protective Groups in Organic Chemistry", Plenum Press (1973).

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