Dihydrocarbazole acetic acid and esters thereof

Details Dihydrocarbazole acetic acid and esters thereof Dihydrocarbazole acetic acid and esters thereof

1978-06-12

1979-03-27

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D20982

Patent

active

041465423

ABSTRACT:
A process for preparing 6-chloro-.alpha.-methylcarbazole-2-acetic acid and esters thereof by the steps of:
(a) reacting 6-chloro-1,2,3,4-tetrahydrocarbazole-2-one with a trialkyl-.alpha.-methylphosphonoacetate to yield the corresponding 3,4-dihydro-.alpha.-methylcarbazole-2-acetic acid ester; and
(b) aromatizing the reaction product of step (a), prior to or after saponification, to yield, respectively, 6-chloro-.alpha.-methylcarbazole-2-acetic acid or ester, is described. Additionally, there are described 6-chloro-1,2,3,4-tetrahydrocarbazole-2-one useful as an intermediate, and dihydrocarbazoles useful as intermediates and/or as anti-inflammatory and antirheumatic agents.

REFERENCES:
berger et al. "Chem. Abstracts", vol. 80 (1974), No. 108366q.

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