Antibiotic FR-900129 substance, a process for the preparation th

Details Antibiotic FR-900129 substance, a process for the preparation th Antibiotic FR-900129 substance, a process for the preparation th

1980-02-28

1982-02-02

Shapiro, Lionel M.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

435128, 435136, 435169, 435886, A61K 3500, C12P 1300

Patent

active

043139353

ABSTRACT:
Prodn. of FR-900129 comprises culturing a Streptomyces n. 4012 category which is analogous to Streptomyces misakiensis and Steptomyces aburaviensis, i.e. Streptomyces avellaneus No. 4012, at 25.degree. C. to 30.degree. C. during 50 to 100 hours in a culture medium which consists of a carbon source (e.g. glucose, fructose, glycerin, starch, galactose, maltose, dextrin), an organic or inorganic nitrogen source (e.g. yeast extract, peptone, cottonseed cake, soyabean powder, cornsteep liquor, dry yeast, ammonium nitrate, ammonium sulphate, ammonium phosphate, urea and amino acid) and an inorganic salt (e.g. calcium carbonate, sodium phosphate, potassium phosphate, sodium chloride, potassium chloride, magnesium salt and copper salt). The produced FR-900129 is isolated by a collecting step, a purifying step, a vacuum condensation step, a freeze-drying step, a pH adjusting step, a cationic, anionic or nonionic resin treating step, an active carbon adsorption step and a crystallizing and recrystallizing step. The isolated material may then be converted to its adduct salt or its ester conventionally.

REFERENCES:
patent: 4169888 (1979-10-01), Hanka et al.

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