Intermediates for the production of N-substituted anilines, inhi

Details Intermediates for the production of N-substituted anilines, inhi Intermediates for the production of N-substituted anilines, inhi

1994-03-22

1995-08-29

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C22934, C07C22936

Patent

active

054461898

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, n, m, o, p, and q are as hereinafter set forth,
and, when R.sub.2 is hydrogen, pharmaceutically acceptable salts thereof with bases, are described. The compounds of formula 1 are potent inhibitors of phospholipases A.sub.2 (PLA.sub.2 's) and are therefore useful in the treatment of inflammatory diseases, such as psosiasis, inflammatory bowel disease, asthma, allergy, arthritis, dermatitis, gout, pulmonary disease, myocardial ischemia/reperfusion, and trauma induced inflammation, such as spinal cord injury.

REFERENCES:
patent: 2655532 (1953-10-01), Hopff et al.
patent: 2781388 (1957-02-01), Mannheimer
patent: 2804474 (1957-08-01), Lew
patent: 3882162 (1975-05-01), Clayton
patent: 4058656 (1977-11-01), Markiewitz et al.
patent: 4234744 (1980-11-01), Effenberger et al.
patent: 4517130 (1985-05-01), Baer
patent: 4603209 (1986-07-01), Tsien et al.
patent: 4734419 (1988-03-01), Hashimoto et al.
patent: 4925958 (1990-05-01), Schmierer et al.
patent: 4985427 (1991-01-01), Waterhouse et al.
Maag et al., Helvetica Chimica Acta, 69, pp. 887-897 (1986).
R. Y. Tsien, Biochemistry, 19, 2396-2404 (1980).
G. Schwarzenbach, A. Willi and R. O. Bach, Helv. Chim. Acta, 30, 1303-1320 (1947).

Affiliated with

Also associated with

Rating

Intermediates for the production of N-substituted anilines, inhi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Intermediates for the production of N-substituted anilines, inhi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intermediates for the production of N-substituted anilines, inhi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1820483