Process for synthesis of FK-506 and tricarbonyl intermediates

Details Process for synthesis of FK-506 and tricarbonyl intermediates Process for synthesis of FK-506 and tricarbonyl intermediates

1990-10-12

1995-08-29

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546245, 548110, 548229, 556 12, 564463, 564305, 560 45, 560174, 560 51, 549 4, 540456, 540452, C07F 718

Patent

active

054461588

ABSTRACT:
A process is described for the total synthesis of the macrolide immunosuppressant, FK-506, and important tricarbonyl process intermediates thereof. The tricarbonyl intermediates can be produced by the mild oxidation of 2,3-dihydroxy carboxylate compounds containing olefin moieties.

REFERENCES:
Jones et al. "J. Am. Chem. Soc." vol. 112, pp. 2998-3017 (1990).

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