Method and apparatus for providing light-activated therapy

Details Method and apparatus for providing light-activated therapy Method and apparatus for providing light-activated therapy

1993-08-16

1995-08-29

Rosenbaum, C. Fred

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

604 19, 604 21, A61N 130

Patent

active

054456088

ABSTRACT:
Light developed by an implantable probe is used to illuminate a treatment site that has been perfused with a photoreactive agent. A number of different embodiments of implantable probes are disclosed. Preferably, an array of light emitting diodes (LEDs) or solid-state laser diodes (LDs) are mounted on a light bar inside the implantable probe and are energized either using a storage battery power source, an inductively coupled external transformer, or with current provided in leads running through a flexible catheter that extends outside the patient's body to an external source. The implantable probe is normally intended to be disposed inside a patient's body during a surgical procedure, at a treatment site, and left in place for several days (or longer) after an incision is closed, while light produced by the array of LEDs or solid-state LDs irradiates the treatment site. Alternatively, light from an external light source can be conveyed over one or more optical fibers to an implantable probe that is disposed inside the patient's body to irradiate the treatment site. Waste heat produced by the array of LEDs or LDs disposed on the implantable probe can be employed to augment the PDT by increasing the temperature of the tissue at the treatment site.

REFERENCES:
patent: 4558690 (1985-12-01), Joyce
patent: 4822335 (1989-04-01), Kawai et al.
patent: 4886831 (1989-12-01), Morcos et al.
patent: 4932934 (1990-06-01), Dougherty et al.
patent: 4957481 (1990-09-01), Gatenby
patent: 5132101 (1992-07-01), Vogel et al.
patent: 5146917 (1992-09-01), Wagnieres et al.
patent: 5163898 (1992-11-01), Morcos et al.
patent: 5298018 (1994-03-01), Narciso, Jr.
Noguchi, H., "The Photodynamic Action of Eosin and Erythrosin upon Snake Venom," J. of Exp. Med., 1906, vol. 8, pp. 252-266.
Bolande et al., "Photodynamic Action," Anch. Path., 1963, vol. 75, pp. 115-122.
Ballio et al., "Research Progress in Organic-Biological and Medicinal Chemistry," .COPYRGT.Societa Editoriale Farmaceutica, 1964, vol. I, pp. 260-336.
Tapper et al., "Photosensitivity from Chlorophyll-Derived Pigments," J. Sci. Fd Agric., 1975, vol. 26, pp. 277-284.
Ison et al., "Phototoxicity of Quinoline Methanols and Other Drugs in Mice and Yeast," The Journal of Investigative Dermatology, 1969, vol. 52, No. 2, pp. 193-198.
Eskins et al., "Sensitized Photodegradation of Cellulose and Cellulosic Wastes," Photochemistry and Photobiology, 1973, vol. 18, pp. 195-200.
Krinsky, N., "Cellular Damage Initiated by Visible Light," Symposia of Society for General Microbiology, 1976, pp. 209-239.
Song et al., "Photochemistry and Photobiology of Psoralens," Photochemistry and Photobiology, 1979, vol. 29, pp. 1177-1197.
Haas et al., "Photodynamic Effects of Dyes on Bacteria," Mutation Research, 1979, vol. 60, pp. 1-11.
Webb et al., "Photodynamic Effects of Dyes on Bacteria," Mutation Research, 1979, vol. 59, pp. 1-13.
Barltrop et al., "Potential Management of Florida Red Tide Through Selective Photodynamic Action," J. Environ. Sci. Health, 1980, A15(2), pp. 163-171.
Parris, J., "Photobiologic Considerations in Photoradiation Therapy," Proceedings of a Porphyrin Photosensitization Workshop, Sep. 28-29, 1981, pp. 91-108.
Bertoloni et al., "Photosensitizing Activity of Water-and Lipid-Soluble Phthalocyanines on Escherichia coli," FEMS Microbiology Letters 71, 1990, pp. 149-156.
Gulliya et al., "Tumor Cell Specific Dark Cytotoxicity of Light-Exposed Merocyanine 540: Implications for Systematic Therapy Without Light," Photochemistry and Photobiology, 1990, vol. 52, No. 4, pp. 831-838.
Kennedy et al., "Photodynamic Therapy with Endogenous Protoporphyrin," J. of Photochemsitry and Photobiology, 1990, No. 6, pp. 143-148.
Gilliya et al., "Preactivation-A Novel Antitumour and Antiviral Approach," Eur f Cancer, 1990, vol. 26, No. 5, pp. 551-553.
Chang et al., "Synergy between Preactivated Photofrin II and Tamoxifin in Killing Retrofibroma, Pseudomyxoma and Breast Cancer Cells," Eur f Cancer, 1991, vol. 27, No. 8, pp. 1034-1038.
Doiron, D., "Instrumentation for Photodynamic Therapy,": Laser Systems for Photobiology and Photomedicine, 1991, pp. 229-230.
Chanh et al., "Preactivated Merocyanin 540 Inactivates HIV-1 and SIV: Potential Therapeutic and Blood Banking Application," J. of Acquired Immune Deficiency Syndrome, 1992, pp. 188-195.
Kirpal et al., "Preactivation: A New Concept for Generation of Photoproducts for Potential Therapeutic Applications," Seminars in Surgical Oncology, Jul./Aug. 1992, vol. 8, No. 4, pp. 250-253.
Ma et al., "Effects of Light Exposure on The Uptake of Photofrin II in Tumors and Normal Tissues," Int. J. Cancer, 1992, vol. 52, pp. 120-123.
Pervaiz et al., "Protein Damage by Photoproducts of Merocyanine 540," Free Radical Biology & Medicine, 1992, vol. 12, pp. 389-396.
Labrousse et al., "Photodynamic Killing of Dictyostelium discoideum Amoebae Mediated by 4', 5'-Diiodofluorescein Isothiocyanate Dextran. A Strategy for The Isolation of Thermoconditional Endocytosis Mutants," Photochemistry and Photobiology, 1993, vol. 67, No. 3, pp. 531-537.
Lytle et al., "Light Emitting Diode Source for Photodynamic Therapy," SPIE, 1993, vol. 1881, pp. 180-188.
Schlager et al., "Immunophototherapy for The Treatment of Cancer of the Larynx," SPIE, 1993, vol. 1881, pp. 148-158.

Affiliated with

Also associated with

Rating

Method and apparatus for providing light-activated therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and apparatus for providing light-activated therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for providing light-activated therapy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1817031