Process for preparing an optical active ester of naphthylpropion

Details Process for preparing an optical active ester of naphthylpropion Process for preparing an optical active ester of naphthylpropion

1982-04-09

1983-11-22

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562401, 562402, C07B 1900

Patent

active

044170700

ABSTRACT:
Disclosed is a process for preparing an optical active alkyl ester of .alpha.-(6-methoxynaphth-2-yl)propionic acid from the racemic modification thereof or from a mixture of the optical isomers thereof by preferential crystallization. The efficiency of the optical resolution can be increased by adding a base which facilitates the racemization. The process comprises dissolving the racemic modification or the optical isomers in an organic solvent such as methanol, ethanol, etc., with or without a base such as sodium methoxide, sodium ethoxide, etc., and seeding seed crystals of one of the optical isomers to effect crystallization for optical resolution.

REFERENCES:
patent: 3803245 (1974-04-01), Lodewijk
patent: 3975432 (1976-08-01), Alvarez
patent: 3980699 (1976-09-01), Fried et al.

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