Process for the preparation of ampicillin

Details Process for the preparation of ampicillin Process for the preparation of ampicillin

1975-03-10

1976-08-31

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602391, C07D49980

Patent

active

039780783

ABSTRACT:
Ampicillin is prepared by reacting an inorganic or organic base with a new penicillin G derivative of the formula: ##EQU1## (wherein R.sub.1 represents a group protecting the carboxy radical and R.sub.2 represents a strong electron-attracting group, e.g. a halogenoethyl group) to open the imidazolidine ring and give an intermediate product of the formula: ##EQU2## and removing by methods known per se the groups --R.sub.1 and R.sub.2 O--CS-- which protect the carboxy radical and amine functions respectively.

REFERENCES:
patent: 3855233 (1974-12-01), Dolfini et al.

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