Substituted pyrrolidinemethanols

Details Substituted pyrrolidinemethanols Substituted pyrrolidinemethanols

1974-02-28

1976-01-27

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603265D, 26032636, 26032645, 26032647, 424274, C07D20708

Patent

active

039352170

ABSTRACT:
Substituted pyrrolidinemethanols of the formula: ##SPC1##
Wherein R.sup.1 and R.sup.2 are each H or C.sub.1.sub.-4 alkyl; R.sup.3, R.sup.4 and R.sup.5 are each H, halogen, C.sub.1.sub.-4 alkyl or C.sub.1.sub.-4 alkoxy, or R.sup.3 and R.sup.4 combinedly form methylenedioxy; and R is C.sub.1.sub.-10 alkyl or a group of the formula: ##SPC2##
Where R.sup.6, R.sup.7 and R.sup.8 are each H, halogen, C.sub.1.sub.-4 alkyl or C.sub.1.sub.-4 alkoxy, or R.sup.6 and R.sup.7 combinedly form methylenedioxy; and pharmaceutically acceptable acid addition salts thereof are disclosed. They are useful as drugs for the treatment of diseases of the heart and circulation.

REFERENCES:
patent: 3108117 (1963-10-01), Wu et al.
patent: 3312716 (1967-04-01), Biel et al.
patent: 3732247 (1973-05-01), Helsley et al.

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