Novel phenoxyaliphatylphenyleneoxyalkyl esters and amides

Details Novel phenoxyaliphatylphenyleneoxyalkyl esters and amides Novel phenoxyaliphatylphenyleneoxyalkyl esters and amides

1987-07-20

1989-04-04

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514333, 514334, 514338, 514339, 514344, 514349, 514350, 514352, 514355, 546256, 546257, 546291, 546273, 546297, 546298, 546286, 546288, 546309, 546310, 546316, 546321, 546322, A61K 31455, C07D21190

Patent

active

048187666

ABSTRACT:
The invention relates to novel 1,4-dihydropyridine-3-carboxylic acid phenoxyaliphatylphenyleneoxyalkyl esters of the formula ##STR1## in which Ac represents an acyl group, X represents oxy or optionally substituted imino, A represents a divalent aliphatic hydrocarbon radical interrupted by a group --X.sub.1 --Ph--X.sub.2 -- in which at least one of the radicals X.sub.1 and X.sub.2 represents oxy and a radical X.sub.1 or X.sub.2 that is other than oxy represents a direct bond, and Ph represents an optionally substituted phenylene radical, and R represents an optionally substituted phenyl, pyridyl or 1-oxidopyridyl, (1,3-dioxa)indanyl or benzofurazanyl radical, R.sub.1 represents an optionally substituted phenyl or indolyl radical, R.sub.2 represents an aliphatic hydrocarbon radical and R.sub.3 represents an aliphatic radical, cyano or amino, and acid addition salts thereof.

REFERENCES:
WO 86/02640 (5/86).
WO 86/04581 (8/86).
Derwent Abstract of Japanese J6 1143359 (7/86).

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