Polynucleotide encoding saliva binding protein

Details Polynucleotide encoding saliva binding protein Polynucleotide encoding saliva binding protein

1996-10-15

1997-12-23

Housel, James C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4241501, 4242371, C07H 2104, A61K 3940, A61K 39085

Patent

active

057009287

ABSTRACT:
Saliva binding protein polypeptides and DNA (RNA) of Staphylococcus aureus encoding such saliva binding protein and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such saliva binding protein for the treatment of infection, particularly bacterial infections. Antagonists against such saliva binding protein and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostics assays for detecting diseases related to the presence of saliva binding protein nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding saliva binding protein family and for detecting the polypeptide in a host.

REFERENCES:
patent: 5422427 (1995-06-01), Russell et al.
Infect Immun 59: 1093-1099 (1991) "Nucleotide sequence of a gene coding for a Saliva-binding protein (SsaB) from Streptococcus sanguis 12 and possible role of the protein in coaggregation with Actinomyces"N. Ganeshkumar, P.M. Hannam, P.E. Kolenbrander, and B.C. McBride.
Infect Immun 63: 703-706 (1995) Cloning of an Enterococcus faecalis Endocarditis Antigen: Homology with Adhesions from Some Oral Streptococci. A.M. Lowe, P.A. Lambert, and A.W. Smith.
Infect Immun 61: 3199-208 (1993) Inactivation of the gene encoding surface protein SspA in Streptococcus gordonii DL1 affects cell interactions with human salivary agglutinin and oral actinomyces. H.F.Jenkinson, S.D.Terry, R.McNab & G.W.Tannock.
J Biol Chem 265: 7120-6 (1990) Streptococcal-host interactions. Structural and functional analysis of a Streptococcus sanguis receptor for a human salivary glycoprotein. D.R.Demuth, E.E.Golub & D.Malamud.
J Dent Res 68: 750-60 (1989) Bacterial adhesion to oral tissues: a model for infectious diseases. R.J.Gibbons.
Infect Immun 56: 2484-90 (1988) Cloning and expression of a Streptococcus sanguis surface antigen that interacts with a human salivary agglutinin. D.R.Demuth, C. A.Davis, A.M.Corner, R.J.Lamont, P.S.Leboy & D.Malamud.
Infect Immun 56: 64-70 (1988) Streptococcus sanguis surface antigens and their interactions with saliva. R.J.Lamont, B.Rosan, G.M.Murphy & C.T. Baker.

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