Styrene derivatives, their use as antiallergic agents and inteme

Details Styrene derivatives, their use as antiallergic agents and inteme Styrene derivatives, their use as antiallergic agents and inteme

1985-10-03

1987-05-12

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514460, 514538, 514708, 514713, 549419, 549423, 549414, 560 12, 560 16, 568 37, 568 45, 568 46, 568 55, A61K 3135, A61K 31235, C07D30910, C07C14710

Patent

active

046650920

ABSTRACT:
Alkenes of the formula (I) and epoxides (II) used to make them are useful as anti-inflammatory and antiallergic pharmaceuticals: ##STR1## wherein R.sup.1 =H or CH.sub.3 ; R.sup.2 =phenyl, substituted phenyl, benzyl or a cysteinyl moiety; R.sup.4 and R.sup.5 =alkyl; n=O or 1; and R.sup.3 is as described.

REFERENCES:
Science, "The Leukotriences in Allergy and Inflammation", vol. 215, 12 Mar. 1982, p. 1380-1383.
Chest, "Leukotriences and Other Lipid Mediators of Asthma", Robert A. Lewis, M.D., vol. 87, No. 1 Jan. 1985, p. 5S-10S.
Drugs, "Leukotriences in Disease Implications for Drug Development", G. A. Higgs and S. Moncada, vol. 30, (1985), p. 1-5.
ACTA Physiologica Scandinavica, "Pulmonary Effects of Leukotrienes", Sven-Erik Dahlen, Stockholm 1983, Supplementum 512, p. 4-6 and 37-38.

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