Compositions and method of treatment for sickle cell anemia

Details Compositions and method of treatment for sickle cell anemia Compositions and method of treatment for sickle cell anemia

1985-03-16

1987-05-12

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514815, 536 41, A61K 3170

Patent

active

046650580

ABSTRACT:
The invention provides a new composition and method for the treatment of sickle cell anemia. The composition includes as an active ingredient an effective amount of the compound, phlorizin benzylazide: ##STR1## and an appropriate pharmaceutical excipient. Load and maintenance dosage ranges as well as effective blood concentration levels for the active ingredient are disclosed.

REFERENCES:
patent: 3833724 (1974-09-01), Cerami et al.
Raper-Ann. Soc. Belge Med. Trop., 1969, 49, 2, 205-210.
Chang, et al, "Comparative Evaluation of Fifteen Anti-Sickling Agents", 1983, pp. 693-704.
Levine, et al, "Cetiedil Inhibition of Calmodulin-Stimulated Enzyme Activity", 1984, pp. 581-584.
Clark, et al, "Hydration of Sickle Cells Using the Sodium Ionophore Monensin", 1982, pp. 1074-1080.

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