Peptide renin inhibitors

Details Peptide renin inhibitors Peptide renin inhibitors

1985-06-17

1987-05-12

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, A61K 3743, C07K 508

Patent

active

046650555

ABSTRACT:
Peptides having the formula: ##STR1## and their use as pharmaceuticals are disclosed. Also disclosed is a process for synthesis of the 4-hydroxyacyl unit of the formula: ##STR2##

REFERENCES:
patent: 3784686 (1974-01-01), Miller
patent: 3873681 (1975-03-01), Miller
patent: 4384994 (1983-05-01), Veber et al.
patent: 4397786 (1983-08-01), Evans et al.
J. Org. Chem. (1985) 50, 4615-25.
K. E. Rittle, et al., J. Org. Chem. 47 3016 (1982).
Boger, et al. Nature 303: 81-84 (1983).
Holladay & Rich, Tetrahedron Lett., 24, 4401 (1983).
Proceedings of the American Peptide Symposium, (1983) 579, Szekle et al.
Corey, E. J. et al., J. Am. Chem. Soc., 87 1353 (1965).
Corey et al., J. Am. Chem. Soc., 94 6190 (1972).

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