Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1977-05-05
1978-10-03
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2602948G, 2602948D, 260302A, 260302R, 424270, A61K 3144, C07D21358
Patent
active
041184963
ABSTRACT:
The compounds are N-(heterocyclomethylthioalkyl)derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkyl-isothioureas. The compounds may also have N'-lower alkyl or N'-(heterocyclomethylthioalkyl)substituents. Three compounds of the invention are S-methyl-N-[2-(5-methyl-4-imidazolyl-methylthio)ethyl]isothiourea, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]acetamidine, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]N"-methylguanidine. The compounds of this invention are histamine H.sub.2 -antagonists.
REFERENCES:
patent: 4049671 (1977-09-01), Durant et al.
patent: 4053473 (1977-10-01), Durant et al.
patent: 4060621 (1977-11-01), Durant et al.
patent: 4070472 (1978-01-01), Durant et al.
Durant Graham John
Ganellin Charon Robin
Young Rodney Christopher
Edgerton William H.
Foggio Richard D.
Keps Joan S.
Rotman Alan L.
Smith Kline & French Laboratories Limited
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