Substituted azol-1-ylmethanes

Details Substituted azol-1-ylmethanes Substituted azol-1-ylmethanes

1975-12-05

1978-10-03

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

260308R, 260465F, 260465G, 260607AR, 260607B, 260609R, 260611R, 260649R, 260649DP, 424269, 424273R, 424273P, 548335, 548345, 548373, 568809, 568705, 568807, A61K 3141, C07D23356, C07D23358, C07D23360

Patent

active

041184874

ABSTRACT:
Azol-1-ylmethanes substituted on the methane carbon atom by (a) phenyl or lower alkyl and (b) by a biphenyl-4-yl, 4-phenoxyphenyl, 4-phenylthiophenyl, 4-phenylsulfinylphenyl or 4-phenylsulfonylphenyl group are antimycotic and antibacterial agents. The compounds, of which (biphenyl-4-yl)phenyl-imidazol-1-ylmethane is a typical example, are prepared from the correspondingly substituted carbinol through treatment with thionyl-bis-azole or from the correspondingly substituted methyl halide with the azole or a derivative thereof.

REFERENCES:
patent: 3801590 (1974-04-01), Draber et al.
patent: 3833603 (1974-09-01), Buchel et al.
patent: 3897438 (1975-07-01), Draber et al.

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