Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1993-10-08
1994-11-01
Russel, Jeffrey E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
435 721, 436501, 436503, 436506, 436507, 436513, 436519, C12Q 102, C12Q 100, G01N 3353, G01N 33567
Patent
active
053607201
ABSTRACT:
By allowing the mast cell enriched population of human conjunctival tissue cells to incubate for a minimum of about forty (40) hours post enzymatic digestion, the treatment window between spontaneous histamine release and anti-human IgE stimulated histamine release is increased. Culturing the human conjunctival tissue mast cells decreases the spontaneous release of histamine and increases the anti-IgE stimulated histamine release, greater than ten fold over spontaneous, at time points over forty (40) hours. This treatment window is sufficient to detect a compound's stabilizing or anti-allergic activity.
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Miller Steven T.
Yanni John M.
Alcon Laboratories Inc.
Gromet Nancy J.
Russel Jeffrey E.
Ryan Patrick M.
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