Process for treating neoplastic disease with azetomicins

Details Process for treating neoplastic disease with azetomicins Process for treating neoplastic disease with azetomicins

1977-07-22

1978-10-03

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, 1951035R, A61K 3702, C07C10352

Patent

active

041184823

ABSTRACT:
Modified actinomycin compounds that incorporate azetidine in the polypeptide component of the actinomycin molecule are disclosed. These compounds are called azetomicins and specifically incorporate an azetidine derivative in the 3' peptide position in at least one of the two polypeptides normally present in actinomycins. The azetomicins are produced by bio-synthetic means from Streptomyces antibioticus that are cultured on a medium including azetidine-2 carboxylic acid and derivatives thereof.

REFERENCES:
patent: 4053460 (1977-10-01), Apple et al.

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