Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Patent
1997-09-03
1999-09-07
Bawa, Raj
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
424443, 424680, 514816, 514817, 514818, 514887, 514944, 514938, 514947, A61K 910
Patent
active
059483890
ABSTRACT:
The present invention is a method for enhancing the analgesic efficacy of a locally applied opioid analgesic or local anesthetic agent in a mammal having an impermeable perineurium barrier sheet about the peripheral sensory nerves at the site of action of the analgesic or anesthetic agent. The method involves applying to that site an effective amount of the analgesic or anesthetic agent dissolved in a hyperosmolar solution having an osmolality of above 300 mOsm/l.
REFERENCES:
European Journal of Pharmacology, 155 (1988) 255-264 "Antinociceptive effects of .mu.- and k-agonists in inflammation are enhanced by a peripheral opioid receptor-specific mechanism."
Neuroscience Letters, 84 (1988) 255-228 "Peripheral effect of fentanyl upon nociception in inflamed tissue of the rat."
The Journal of Pharmacology and Experimental Therapeutics, vol. 248, No.3, pp. 1269-1275 (1989) by The American Society for Pharmacology and Experimental Therapeutics. "Pheripheral Opioid Receptors Mediating Antinociception in Inflammation. Evidence for Involvement of Mu, Delta and Kappa Receptors."
Proc. Natl. Acad. Sci. USA, vol. 87, pp. 5935-5939, Aug. 1990, "Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in Inflammation."
The Journal of Neuroscience, Apr. 1990 10(4): 1292-1298, "Intrinsic Mechanisms of Antiociception in Inflammation: Local Opiod Receptors and .beta.-Edorphin."
The New England Journal of Medicine 325:1123-1126 (Oct. 17, 1991). "Analgesic Effect of Intraarticular Morphine After Arthroscopic Knee Surgery."
Anesthesiology 77:263-266, (1992). "Intraarticular Morphine, Bupivacaine, and Morphine/Bupivacaine for Pain control after Knee Videoarthroscopy."
The Lancet--vol. 342, Aug. 7, 1993, pp. 320-324 "Local analgesic effect of endogenous opioid peptides."
Anesth Analg 1993;76:182-91, "Peripheral Mechanisms of Opioid Analgesia."
Critical Review in Neurobiology, vol. 5, Issue 3 (1990), pp. 265-311. "Microenvironment of the Peripheral Nervous System Under Normal and Pathological Conditions."
Current Opinion in Anaesthesiology (1994) 7:347-351. "Pheripheral and non-neuronal opioid effects."
The Journal of Neuroscience, Jan. 1995, 15(1): 165-172. "Perineurial Defect and Peripheral Opioid Analgesia in Inflammation."
Pharmacology Biochemistry & Behavior, Vo. 31, pp. 445-451 (1988). "Unilateral Inflammation of the Hindpaw in Rats as a Model of Prolonged Noxious Stimulation: Alterations in Behavior and Nociceptive Thresholds."
Current Opinion in Anaesthesiology (1993), 6:400-408. "Small-volume resuscitation."
Thorstud, G.K. Pleural reactions to irritants. Acta Chir. Scaud. 1965; 355. Supp:1-74.
Agon et al. (1988). J. Pharm. Pharmacol. 40(8):539-43.
Bawa Raj
El Khoury & Stein, Ltd.
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