Liquid stable thiol activator

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase

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Details

435 17, 435188, C12Q 148, C12N 996

Patent

active

057006539

ABSTRACT:
An aqueous, liquid-stable thiol activator solution is disclosed. The solution can include a thiol activator, such as N-acetyl-L-cysteine and a stabilizing agent, such as mannitol. The thiol is stabilized in the aqueous solution for at least about one year under storage conditions and for at least about 28 days under open-bottle conditions. The solution can be used as a reactivator of creatine kinase catalytic activity.

REFERENCES:
patent: H622 (1989-04-01), Kageyama
patent: 4118279 (1978-10-01), Determann
patent: 4339533 (1982-07-01), Chu
patent: 4740458 (1988-04-01), Kondo
patent: 4883762 (1989-11-01), Hoskins
patent: 4888289 (1989-12-01), Takami
patent: 5023235 (1991-06-01), N'Guyen
patent: 5096926 (1992-03-01), Fiorini et al.
patent: 5192657 (1993-03-01), Jarway
patent: 5298406 (1994-03-01), Loyd
Sandifort; "Effects of Ethylene Diamine-tetraacetate on CK-NAC Reagent Starilay and Measured Creatine Kinase Activities", Clin. Chem. (23) 11, p. 2169 ets., (1977).
Nealon; "Activation of Human Creatine Kinase Isuenzymes By pH and Various Sulfhydryl and Chelating Agents", Clin Chem,(27) No. 3, p. 402 ets., (1981).
Horder, "IFCC Methods for the Measurement of Catalytic Concentrations of Enzymes"JIFCC, Feb. (1990) p. 26 et.s.
Greenwald, "Therapeutic Usages of Oxygen Radical Scavengers in Human Iron, and Metal Chelating Agents", Free Rad. Res. Comm., vol 16, No. 1, pp. 1-10 (1992).
Zimmerman, "Therapeutic Application of Oxygen Radial Scavengers", Chest, (100), #3, p. 1895 ets, Sep. 1991.
Gee; "Clastogenic and Mutagenic Actions of Active Species Generated in the 6-Hydroxydopamine/Oxygen Reaction"; Effects of Scavengers of Active Oxygen .

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