Antibiotically active aminopapulacandin derivatives

Details Antibiotically active aminopapulacandin derivatives Antibiotically active aminopapulacandin derivatives

1981-12-14

1983-02-15

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 168, A61K 3171, C07H 1304

Patent

active

043741290

ABSTRACT:
N-acylated 11-amino derivatives of papulacandin A or B of the formula I ##STR1## in which Pap is the remainder of papulacandin A or B, R represents methyl or hydrogen and Ac represents the acyl radical of an organic acid, including salts of compounds with salt-forming properties, are distinguished by their antibiotic, especially antimycotic, action and can be used for combating infections of that type, especially those caused by Candida albicans. The compounds are produced according to conventional processes from corresponding 11-unsubstituted papulacandin derivatives.

REFERENCES:
patent: 3956274 (1976-05-01), Umezawa et al.
patent: 3960833 (1976-06-01), Naito et al.
patent: 4251517 (1981-02-01), Traxler
patent: 4278665 (1981-07-01), Traxler et al.
P. Traxler et al., Journal of Antibiotic, 33, 967/1980.

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