Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1982-09-30
1985-05-07
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
2602433, C07D49514, A61K 3155
Patent
active
045157928
ABSTRACT:
Tetracyclic heterocycles of the formula ##STR1## wherein Th is the residue completing a fused thiophen ring, X represents oxo, hydroxyl together with hydrogen, or preferably two hydrogens, R.sup.1 represents lower alkyl, lower alkoxy, chloro, bromo, trifluoromethyl or, preferably, hydrogen, and R.sup.2 represents hydroxy-lower alkyl, aryl-lower alkyl, or, preferably, lower alkyl, especially methyl, or hydrogen, and therapeutically acceptable acid addition salts thereof are especially useful as antidepressants, in particular in the form of appropriate pharmaceutical compositions. They are obtainable by conventional synthetic methods of organic chemistry.
REFERENCES:
patent: 4025513 (1977-05-01), Olivie
patent: 4062848 (1977-12-01), Van der Burg
patent: 4128641 (1978-12-01), Van der Burg
patent: 4316900 (1982-02-01), Wasley
patent: 4333935 (1982-06-01), Van der Burg
Nickolson et al., J. Pharm. Pharmacol. 33, 760, (1981).
Watthey et al., Medicinal Chemistry, vol. 26, 1116-1122, (1983).
Ciba-Geigy Corporation
Gruenfeld Norbert
Hollrah Glennon H.
Springer D. B.
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