Treatment of human viral infections

Details Treatment of human viral infections Treatment of human viral infections

1987-10-21

1989-04-04

Rollins, John W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424451, 424464, 424DIG15, 514 50, 514960, 514962, 514966, 514967, 604415, A61K 948, A61K 944

Patent

active

048185388

ABSTRACT:
Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof.
Also disclosed is the use of the 5.dbd.-mono-, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose.

REFERENCES:
Imazawa, J. Org. Chem. 43(15): 3044, 3048, 1978.
Horwitz, J. Org. Chem. 29:2076-2078, 1964.
Glinski, J. Org. Chem. 38(25): 4299-4305, 1973.
Shannon, Science 284: 472-507, 1977.
DeClercq et al., Biochem Pharm., vol. 29, pp. 1849-1851, 1980.
Lin et al., J. Med. Chem., vol. 26: 1691-1696, 1983.
Krieg et al., Exp. Cell Res., vol. 116:21-29, 1978.

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