Azetidinyl acetonitrile and acetamide antiarrhythmia composition

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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260239A, 424263, 546275, A61K 3144, A61K 31395, C07D40106, C07D20504

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active

041338812

ABSTRACT:
.alpha.-(1-R-3-Azetidinyl)-.alpha.-phenyl-.alpha.-substituted-acetamides and -acetonitriles represented by the following formula: ##STR1## wherein R represents hydrogen, lower alkyl, lower cycloalkyl or phenyllower alkyl, R.sup.1 represents phenyl or 2-pyridyl, and Y is carbamoyl or cyano having antiarrhythmic activity are disclosed. Pharmaceutically acceptable acid addition salts of the free bases and quaternary salts are included as part of the invention.

REFERENCES:
patent: 3318869 (1967-05-01), Cusic
Higgins et al., Chem. Abs. 77, 126337y (1972).

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