Antihistaminic compositions and methods containing pyridine deri

Details Antihistaminic compositions and methods containing pyridine deri Antihistaminic compositions and methods containing pyridine deri

1985-07-08

1987-03-17

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144

Patent

active

046508074

ABSTRACT:
This disclosure describes a compound of Formula I ##STR1## (including its pharmaceutically acceptable salts and esters) which has potent antihistamine activity which is substantially free from sedative effects and which has little or no anticholinergic effects.

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patent: 4307245 (1981-12-01), Hu et al.
patent: 4355036 (1982-10-01), Villani
patent: 4501893 (1985-02-01), Findlay et al.
Chemical Abstracts 71:11415f (1969).
J. Med. Chem. 1980, 23, 149-153, Synthesis and Psychoanaleptic Properties of New Compounds, Structurally Related to Diphenhydramine, Buzas et al., Drug Metabolism and Disposition, vol. 9, No. 5, 1981.
Aspet 1980, Abstract PDR-1978; pp. 707 and 708, Actidil and Actifed-C.

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