Substituted 1,5-benzodiazepine compounds

Details Substituted 1,5-benzodiazepine compounds Substituted 1,5-benzodiazepine compounds

1986-07-18

1987-03-17

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540567, A61K 3155, C07D24312

Patent

active

046507973

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1 is alkyl, alkenyl, alkynyl, cycloalkyl, or substituted alkyl, and R.sub.4 is aryl or heterocyclo are disclosed. These compounds are useful as cardiovascular agents and especially as anti-hypertensive agents.

REFERENCES:
Miyano et al., Synthesis of 3,3-Dimethyl-2,3,4,5,10,11-hexahydro-11-phenyl-1H-dibenzo[b,e][1,4]-diazep in-1-one, A New Tricyclic System Chem. Pharm. Bull., 20(7) 1588-1589 (1972).
Okamoto et al., "A Direct Reductive Deamination . . . " Chem. Pharm. Bull 29(4), 1165-1169 (1981).

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