Proteins associated with cell proliferation

Details Proteins associated with cell proliferation Proteins associated with cell proliferation

1997-12-04

2000-06-27

Hutzell, Paula K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 232, C07H 2104, C07H 2102

Patent

active

060808470

ABSTRACT:
The invention provides three human proteins associated with cell proliferation, referred to collectively as "APOP" and individually as "APOP-1", "APOP-2", and "APOP-3", and polynucleotides which identify and encode APOP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for preventing and treating disorders associated with expression of APOP.

REFERENCES:
Hengartner, M.O. and H.R. Horvitz, "C. elegans Cell Survival Gene ced-9 Encodes a Functional Homolog of the Mammalian Proto-Oncogene bcl-2", Cell, 76:665-676 (1994).
Oltvai, Z.N. et al., "Bcl-2 Heterodimerizes In Vivo with a Conserved Homolog, Bax, That Accelerates Programed Cell Death", Cell, 74:609-619 (1993).
Yin, X.-M., et al., "BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax", Nature, 369:321-323 (1994).
Yang, E. et al., "Bad, a Heterodimeric Partner for Bcl-x.sub.L and Bcl-2, Displaces Bax and Promotes Cell Death", Cell, 80:285-291 (1995).
Kim, D. et al., "A cDNA encoding a putative 37 kDa leucine-rich repeat (LRR) protein, p37NB, isolated from S-type neuroblastoma cell has a differential tissue distribution", Biochim. Biophys. Acta, 1309:183-188 (1996).
Bengtsson, E. et al., "The Primary Structure of a Basic Leucine-rich Repeat Protein, PRELP, Found in Connective Tissues", J. Biol. Chem., 270:25639-25644 (1995).
Shibahara, K. et al., "Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death", Gene, 166:297-301 (1995) (GI 1384077; GI 1384078).
Onishi, Y. and H. Kizaki, "Molecular Cloning of the Genes Suppressed in RVC Lymphoma Cells by Topoisomerase Inhibitors", Biochim. Biophys. Res. Commun., 228:7-13 (1996).
Yin, D.X. et al., (Direct Submission), GenBank Sequence Database (Accession 1683637), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1683636; GI 1683637) Jan. 16, 1997.
Yin, D.X. et al., (Direct Submission), GenBank Sequence Database (Accession U66879), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1683636; GI 1683637) Nov. 23, 1996.
Kim, D. et al., (Direct Submission), GenBank Sequence Database (Accession 1236329), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1236328; GI 1236329) Apr. 18, 1997.
Kim, D. et al., (Direct Submission), GenBank Sequence Database (Accession U32907), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1236328; GI 1236329) Apr. 18, 1997.
Shibahara, K. et al., (Direct Submission), GenBank Sequence Database (Accession 1384078), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1384077; GI 1384078) Jan. 10, 1999.
Shibahara, K. et al., (Direct Submission), GenBank Sequence Database (Accession D50465), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1384077; GI 1384078) Jan. 10, 1999.
Matsuhashi, S. et al., (Direct Submission), GenBank Sequence Database (Accession 1825562), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1825561; GI 1825562) Apr. 21, 1997.
Matsuhashi, S. et al., (Direct Submission), GenBank Sequence Database (Accession U83908), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1825561; GI 1825562) Feb. 7, 1997.
Wang et al, Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria, Cell 87: 629-638, and attached sequence comparison, Nov. 15, 1996.
Adams et al, The Genome Directory, Nature 377 (Suppl), 3-174 (Sequence Comparison), Sep. 28, 1995.
Kim et al, A cDNA encoding a putative 37 kDa leucine-rich repeat (LRR) protein, p37NB, isolated from S-type neuroblastoma cell has a differential tissue distribution, Biochimica et Biophysica Acta 1309: 183-188, Nov. 30, 1996.
Shibahara et al, Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death, Gene 166: 297-301, Oct. 17, 1995.
Current Protocols in Molecular Biology vol. 2, Chapter 16, Ed. Ausubel et al, John Wiley and Sons, New York, NY, 1990.
Azzoni et al, Genbank Accession No.: O15501, Apr. 30, 1997.

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