Process for the preparation of 2-(4-[4-(4-chloro-1-pyrazolyl)but

Details Process for the preparation of 2-(4-[4-(4-chloro-1-pyrazolyl)but Process for the preparation of 2-(4-[4-(4-chloro-1-pyrazolyl)but

1994-05-09

1996-07-16

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D40114

Patent

active

055368360

ABSTRACT:
The present invention relates to a process for the preparation of 2-{4-[4-(4-chloro-1-pyrazolyl)buty1]-1-piperazinyl}pyrimidine (Lesopitron) of formula I: ##STR1## characterized in that the reaction between 2-(1-piperazinyl)pyrimidine, 4-chloropyrazole and the carbon chain of formula (III) ##STR2## in which X and Y, which may be identical or different, represent a suitable leaving group, is carried out in a single step in a suitable solvent.

REFERENCES:
patent: 4351939 (1982-09-01), Simms et al.
patent: 4423049 (1983-12-01), Temple, Jr.
patent: 4524206 (1985-06-01), New et al.
patent: 4892943 (1990-01-01), Abou-Gharbia
patent: 5162323 (1992-11-01), Frigola-Constansa et al.
patent: 5227486 (1993-07-01), Merce-Vidal et al.

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