Organosulfonyl salts of 2,3'-O-cyclocytidine

Details Organosulfonyl salts of 2,3'-O-cyclocytidine Organosulfonyl salts of 2,3'-O-cyclocytidine

1994-12-15

1996-07-16

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 49, C07H 19067, A61K 3170

Patent

active

055368247

ABSTRACT:
Compounds of Formula IV: ##STR1## are described. In the compounds of Formula IV, R.sup.6 is selected from a trifluoromethyl group, a C.sub.1 -C.sub.6 alkyl group and a C.sub.6 -C.sub.9 aryl group, and R.sup.1 is selected from hydrogen, trityl, methoxytrityl, dimethoxytrityl, acetyl, a C2-C6 alkylacyl group, a C6-C9 arylacyl group, allyl, 2,2,2-trichloroethyl, phosphates and salts thereof, tosyl and mesyl. The above organosulfonyl salts of 2,3'-O-cyclocytidine are intermediates in the preparation of 1-(B-D-xylopentofuranose)cytosine, an inhibitor of DNA synthesis.

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Chemical Abstracts, vol. 86, p. 583, Abstract # 121712t, 1977.
Ozaki et al., Japan Kokai 76, 113, 881, Oct. 7, 1976.

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