Imidazolidin-4-one derivatives useful as anticancer agents

Details Imidazolidin-4-one derivatives useful as anticancer agents Imidazolidin-4-one derivatives useful as anticancer agents

1998-12-28

2000-06-27

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514361, 514385, 514400, 514402, 5462727, 5483127, 5483164, A01N 4350, A01N 4364, A01N 4382, C07D40314, C07D40302

Patent

active

060807695

ABSTRACT:
The present invention relates to compounds of formula 1 ##STR1## and to pharmaceutically acceptable salts and solvates thereof, wherein Z, R, R.sup.3 and R.sup.4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of inhibiting abnormal cell growth, including cancer, in a mammal by administering the compounds of formula 1 to said mammal.

REFERENCES:
Nancy E. Kohl, et al., "Selective Inhibition of ras-Dependent Transformation by Farnesyltransferase Inhibitor", Science, vol. 260, pp. 1934-1937, (1993).

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