Dinucleoside-5', 5'-pyrophosphates administered to treat HIV

Details Dinucleoside-5', 5'-pyrophosphates administered to treat HIV Dinucleoside-5', 5'-pyrophosphates administered to treat HIV

1998-07-01

2000-06-27

Crane, L. Eric

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 48, 514 50, 514 51, 536 2623, 424417, A61K 3170

Patent

active

060807318

ABSTRACT:
5',5'-Pyrophosphates of non-naturally occurring nucleosides selected from thymine-3'-azido-2',3'-dideoxy-D-riboside, 5-fluorouracil-2'-deoxy-D-riboside, uracil-3'-azido-2',3'-dideoxy-D-riboside, guanine-2',3'-dideoxy-D-riboside, hypoxanthing-2',3'-dideoxy-D-riboside, cytosine-2',3'-dideoxy-D-riboside, and adenine-2',3'-dideoxy-D-riboside, are described as well as their manufacture and use as therapeutical pharmaceutical compositions or as pro-drugs encapsulated into biological carriers, e.g., transformed erythrocytes, for targeting to specific cell population responsible of the development of the pathological disorders.

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