Rinse solution for organs and tissues

Details Rinse solution for organs and tissues Rinse solution for organs and tissues

1995-11-22

2000-06-27

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514667, 435 1, A61K 3170, A61K 3113, A01N 102

Patent

active

06080730&

ABSTRACT:
Disclosed is a rinse solution for rinsing organs and tissues prior to transplantation. The solution comprises, in one liter of solution: from 2 mM to 50 mM glycine; from 0.12 to 1.2 mM adenosine; monosaccharide, sodium, potassium, calcium and magnesium ions; and water for injection sufficient to make a liter of solution; said solution having a pH of about 6.0 to 7.5 and a concentration of potassium of less than 6 MEQ/L. Methods of making and using the solutions are also disclosed.

REFERENCES:
patent: 5066578 (1991-11-01), Wikman-Coffelt
patent: 5104859 (1992-04-01), Sollevi
patent: 5145771 (1992-09-01), LeMasters et al.
Gao et al., "Evidence that Adenosine Is a Key Component in Carolina Rinse Responsible for Reducing Graft Failure After Orthotopic Liver Transplanation in the Rat," Transplantation, 52(6), 992-998 (1991).
Currin (LeMasters) et al.(I), "Evidence that Carolina Rinse Solution Protects Sinusoidal Endothelial Cells Against Reperfusion Injury After Cold Ischemic Storage of Rat Liver,"Transplantation, 50(6), 1076-1077 (Dec. 1990).
Marsh et al.(I), "Hypothermic Preservation of Hepatocytes. III. Effects of Resuspension Media on Viability After Up To 7 Days of Storage," Hepatology, 13(3), 500-508 (1991).
Marsh et al. (II), "Glycine Prevention of Cold Ischemic Injury in Isolated Hepatocytes," Cryobiology, 28, 105-109 (1991).
Weinberg et al.(I), "Amino Acid Protection of Cultured Kidnay Tubule Cells Against Calcium Ionophore-Induced Lethal Cell Injury," Laboratory Investigation, 65(6), 671-678 (1991).
Weinberg et al.(II), "Metabolic Aspects of Protection by Glycine Against Hypoxic Injury to Isolated Promixal Tubules," J. Am. Soc. Nephrology, 1(7), 949-958 (1991).
Schnellmann, "Renal Mitochondrial Glutathione Transport," Life Sciences, 49(5), 393-398 (1991).
Schilling et al., "Membrane Stabilizing Effects of Glycine During Kidney Cold Storage and Reperfusion," Transplantation Proceedings, 23(5), 2387-2389 (1991).
den Butter et al.(I), "Amino Acids to Suppress Reperfusion Injury After Liver Preservation," Transplantation Proceedings, 23(5), 2378-2379 (1991).
Weinberg, "Glutathione and Glycine in Acute Renal Failure," Renal Failure, 14(3), 311-319 (1992).
Weinberg et al. (IV), "Protection of Human Umbilical Cord Vein Endothelial Cells by Glycine and Structurally Similar Amino Acids Against Calcium and Hydrogen Peroxide-Induced Lethal Cell Injury," Am. J. Pathology, 140(2), 457-471 (1992).
Dickson et al., "Glycine Cytoprotection During Lethal Hepatocellular Injury From Adenosine Triphosphate Depletion." Gastroenterology, 102(6), 2098-2107 (1992).
Marsh et al. (III), "Glycine Protects Hepatocytes from Injury Caused by Anoxia, Cold Ischemia and Mitochondrial Inhibitors, But Not Injury Caused by Calcium Ionophores or Oxidative Stress," Hepatology, 17(1), 91-98 (1992).
Bachmann et al. (I), "Warm Carolina Rinse Solution Prevents Graft Failure From Storage Injury After Orthotopic Rat Liver Transplantation with Arterialization," Transplant International, 5, 108-114 (1992).
Ferguson et al., "An Increase in Cytosolic Protease Activity During Liver Preservation," Transplantation, 55(3), 627-633 (1993).
den Butter et al. (II), "Effect of Glutathione and Glycine in Kidney Preservation," Transplantation Proceedings, 25(1), 1633-1634 (1993).
Sanchez-Urdazpal et al., "Carolina Rinse Solution Decreases Liver Injury During Clinical Liver Transplantation," Transplantation Proceedings, 25(1), 1574-1575 (1993).
Currin et al.(II), "Inhibition of Tumor Necrosis Factor Release From Cultured Rat Kupffer Cells by Agents that Reduce Graft Failure from Storage Injury," Transplantation Proceedings, 25(1), 1631-1632 (1993).
Bachmann et al. (II), "Ultrastructural Correlates of Liver Graft Failure From Storage Injury: Studies of Graft Protection by Carolina Rinse Solution and Pentoxifylline," Transplanation Proceedings, 25(1), 1620-1624 (1993).
Belzer et al., "Principles of Solid-Organ Preservation by Cold Storage," Transplantation, 45(4), 673-676 (Apr. 1988).

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