Pulmonary delivery of active fragments of parathyroid hormone

Details Pulmonary delivery of active fragments of parathyroid hormone Pulmonary delivery of active fragments of parathyroid hormone

1998-08-03

2000-06-27

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 530399, 424489, A61K 3829

Patent

active

060807210

ABSTRACT:
Systemic delivery of parathyroid hormone to a mammalian host is accomplished by inhalation through the mouth of a dispersion of an N-terminal fragment of PTH. It has been found that such respiratory delivery of the PTH fragment provides a pulsatile concentration profile of the PTH in the host's serum. PTH fragment compositions include dry powder formulations having the PTH present in a dry bulking powder, liquid solutions or suspensions suitable for nebulization, and aerosol propellants suitable for use in a metered dose inhaler.

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Patton, Modern Drug Discovery, 19-28, 1998.

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