Substituted quinoline-2-carboxamides, their preparation and thei

Details Substituted quinoline-2-carboxamides, their preparation and thei Substituted quinoline-2-carboxamides, their preparation and thei

1996-07-03

1998-02-17

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546156, A61K 3147, C07D21520, C07D21560

Patent

active

057191646

ABSTRACT:
The invention relates to substituted quinoline-2-carboxylic acid amides of the formula I ##STR1## their preparation and their use, and intermediates which are formed in the preparation of the compounds of the formula I. The compounds according to the invention are used as inhibitors of prolyl 4-hydroxylase and as pharmaceuticals (medicaments) for treatment of fibrotic diseases.

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