Preparation process of .alpha.-L-aspartyl-L-phenylalanine methyl

Details Preparation process of .alpha.-L-aspartyl-L-phenylalanine methyl Preparation process of .alpha.-L-aspartyl-L-phenylalanine methyl

1988-03-22

1989-01-31

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 41, 426548, C07C10132, A23L 1236

Patent

active

048017329

ABSTRACT:
This invention relates to an improved process for preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester. More specifically, it relates to a process for preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester which comprises treating, as a raw material, N-formyl-.alpha.-L-aspartyl-L-phenylalanine in methanol in the presence of an acid to form .alpha.-L-aspartyl-L-phenylalanine dimethyl ester, hydrolyzing the .alpha.-L-aspartyl-L-phenylalanine dimethyl ester by bringing it into contact with hydrochloric acid in the presence of methanol as desired, separating the thereby-precipitated .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride and neutralizing the hydrochloride. Further, this invention also provides a process for preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester capable of using, as a raw material, N-formyl-.alpha.-L-aspartyl-L-phenylalanine which contains N-formyl-.beta.-L-aspartyl-L-phenylalanine in an amount of 30% by weight or less.

REFERENCES:
patent: 3879372 (1975-04-01), Boesten
patent: 3933781 (1976-01-01), Bachman et al.
patent: 4021418 (1977-05-01), Takemoto et al.
patent: 4071511 (1978-01-01), Takemoto et al.
patent: 4088649 (1978-05-01), Smith et al.
patent: 4153737 (1979-05-01), Berg et al.
patent: 4634790 (1987-01-01), Shinohara et al.
Chemical Abstracts, 105:153551s.
English-language abstract (World Patent Index) 85-244397/40.

Affiliated with

Also associated with

Rating

Preparation process of .alpha.-L-aspartyl-L-phenylalanine methyl does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation process of .alpha.-L-aspartyl-L-phenylalanine methyl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation process of .alpha.-L-aspartyl-L-phenylalanine methyl will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-178426