Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1993-05-04
1994-11-08
Wityshyn, Michael G.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530413, C07K 320, C07K 1506
Patent
active
053628578
ABSTRACT:
The invention relates to a process for the purification by immunoaffinity chromatography of plasminogen activator inhibitor 2 (PAI-2) and to monoclonal antibodies which are suitable for a process of this type.
REFERENCES:
patent: 5134065 (1992-07-01), Sanzo et al.
patent: 5204256 (1993-04-01), Radtke et al.
Astedt, B., et al., "Purification of a Specific Placental Plasminogen Activator Inhibitor by Monoclonal Antibody and Its Complex Formation with Plasminogen Activator," Medline Abstract No. 85193106 (1985).
Radtke, K. P., et al., "Isolation of Plasminogen Activator Inhibitor-2 (PAI-2) from Human Placenta," Medline Abstract No. 91214546 (1990).
Astedt, B., et al., "Purification of a Specific Placental Plasminogen Activator Inhibitor by Monoclonal Antibody and Its Complex Formation with Plasminogen Activator," Thrombosis and Haemostasis: 122-125 (F. K. Schattauer Verlag GmbH, 1985).
Abstract of German Patent Application No. DE 3722673, entitled: "New DNA Encoding Complete Plasminogen Activator Inhibitor Type 2-Expressed Protein and Derived Antibodies, Useful Therapeutically and Diagnostically".
"Purification of a Specific Placental Plasminogen Activator Inhibitor by Monoclonal Antibody and Its Complex Formation with Plasminogen Activator", Astedt et al., Thrombosis and Haemostasis, 53:122-125 (1985).
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"Isolation of Plasminogen Activator Inhibitor-2 (PAI-2) from Human Placenta", Radtke et al., Biol. Chem. Hoppe-Seyler, 371:1119-1127 (1990).
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"Plasmid Vectors Carrying the Replication Origin of Filamentous Single-Stranded Phages", Cesareni et al., Genetic Engineering, 9:135-154 (1987).
"Expression of the human blood coagulation protein Factor XIIIa in Saccharomyces cerevisiae: dependence of the expression levels from host-vector systems and medium conditions", Broeker et al., Applied Microbiology and Biotechnology, 34:756-764 (1991).
Wun et al., "An Inhibitor of Plasminogen Activator . . . ", Jour. of Biol. Chem., vol. 262, No. 6, 1987 pp. 3646-3653.
Harris, E. L. V. et al., "Protein Purification Methods", IRL Press, 1989, pp. 255-257.
Behringwerke Aktiengesellschaft
Sayala C.
Wityshyn Michael G.
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